Tropical Journal of Pharmaceutical Research

Original Research Article | OPEN ACCESS

Combination of lateral ventricular puncture and catheterization with different doses of urokinase in the treatment of ventricular hemorrhage under CT multimodal imaging

Zhifu Song¹, Yulan Gan², Xueping Huang¹, Xiaolin Huang¹, Gonghong Liu¹, Bing Kong¹, Wenyou Wu¹

¹Department of Neurosurgery, Luzhou 646000, Sichuan Province, China; ²Department of Neonatology, Luzhou People's Hospital, Luzhou 646000, Sichuan Province, China.

For correspondence:- Wenyou Wu Email: hdcs2f@163.com Tel:+8618090168021

Accepted: 29 November 2021 Published: 31 December 2021

Citation: Song Z, Gan Y, Huang X, Huang X, Liu G, Kong B, et al. Combination of lateral ventricular puncture and catheterization with different doses of urokinase in the treatment of ventricular hemorrhage under CT multimodal imaging. Trop J Pharm Res 2021; 20(12):2645-2651 doi: 10.4314/tjpr.v20i12.27

© 2021 The authors.
This is an Open Access article that uses a funding model which does not charge readers or their institutions for access and distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) and the Budapest Open Access Initiative (http://www.budapestopenaccessinitiative.org/read), which permit unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited..

Abstract

Purpose: To study the clinical effectiveness of lateral ventricular puncture and catheterization in combination with urokinase in the treatment of intraventricular hemorrhage (IVH) under computed tomography (CT) multimodal imaging.

Methods: Eighty-four IVH patients were selected and assigned to high- and low-dose urokinase groups. The clinical efficacy of the combination of lateral ventricle puncture and drainage at different doses of urokinase under CT multimodal imaging in the treatment of IVH, was determined.

Results: Compared with the low-dose urokinase group, postoperative waking time, postoperative extubation time and discharge time in the high-dose group were markedly better in high-dose urokinase group, while GCS score after treatment was lower in the high-dose group, with higher total effectiveness in the high-dose urokinase group. There was a significantly higher hematoma clearance in the high-dose group on the 3rd day of treatment (p < 0.001), while the total incidence of postoperative complications were markedly lower in the high-dose group (p < 0.05).

Conclusion: The combination of lateral ventricular puncture and drainage with high-dose urokinase under CT multimodal imaging enhances the recovery of consciousness in IVH patients. Therefore, the combined treatment has great potentials for clinical application.

Keywords: CT multimodal imaging, Lateral ventricular puncture, Catheterization, Urokinase, Ventricular hemorrhage (IVH)